This paper presents the design, analysis, fabrication, and testing of a series of two degrees of freedom (2-DOF) Remote Center of Motion (RCM) flexure hinges. These hinges are constructed using planner generalized cross-spring pivots according to the building block approach. Load–rotation relationships for the flexure hinge are established through the beam constraint method, with finite element analysis confirming theoretical predictions and elucidating parametric dependencies of critical dimensions. An illustrative application of the flexure hinge is presented, showcasing its capability to transform planar linear motion into spatial 2-DOF RCM movements. Experimental validation substantiates the functionality and efficacy of the designed mechanism, reinforcing its potential practical applications.