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Wavelet-based photoacoustic viscoelastographic microscopy using photoacoustic damped oscillation effect

Authors: Yang Liu; Zilong Zou; Simin Wang; Chao Tao; Zizhong Hu; Xiaojun Liu;

Wavelet-based photoacoustic viscoelastographic microscopy using photoacoustic damped oscillation effect

Abstract

Viscoelastic characterization of biological tissue has significant biomedical value. In this study, we propose a wavelet-based photoacoustic viscoelastographic microscopy to characterize the viscoelasticity of tissues beneath the optical scattering depth from photoacoustic oscillation signals. Irradiated by laser pulses, biological tissue absorbs energy, expands, continues oscillating, and emits damped transient ultrasonic waves, i.e., photoacoustic oscillation signals, for a short time. A damped oscillation wavelet is applied to map photoacoustic oscillation signals into a representation of time, frequency, and decay rate. We can evaluate the frequency and decay rate of the photoacoustic oscillation signals. By considering the interrelationships among frequency, decay rate, shear modulus, and shear viscosity coefficient, we can generate images that depict the shear modulus image and shear viscosity coefficient image within the tissue. These images of the shear modulus and shear viscosity coefficient collectively form the viscoelastogram of the tissue, offering a comprehensive portrayal of its viscoelastic properties. Our study has potential biomedical value and may improve the accurate diagnosis of diseases and achieve more effective early interventions.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Top 10%
Average
Average
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