The concept of Fano resonance originally discovered in quantum systems has been introduced to the field of optics for the last decade and more. One distinctive feature of the resonance lies in its asymmetric line shape. Graphene metamaterials have attracted much attention for making tunable devices due to the controllable carrier density of graphene. As realizing Fano resonance in graphene metamaterials, asymmetric and tunable optical responses are usually observed in transmission or reflectance spectra. This Perspective is intended to review the current developments on Fano-resonant graphene metamaterials, which are divided into three categories based on the participation of graphene plasmon in Fano resonance. Later, discussions on the applications in sensors, switches, modulators, and slow-light devices are given, and a future perspective is proposed.