The design of structure includes a significant parameter, which is seismic analysis. The earthquake designing for a structure depends on the ductility and strength of frame members. The response reduction value depends on the structure’s ductility and strength, thus contributing to the super structure’s seismic design. The design of the substructure focuses mainly on the type of soil. The soil-structure interaction varies according to different types of soil, categorized as soft soil, medium soil, and hard rock soil. As per the Indian Design standards, the R-Value is used in the calculation of design base shear. Instead of considering the tabulated value from the IS 1893-2016[8], the calculation of R-Value can be used in optimizing the design. This study aims at calculating various response reduction values obtained from the regular and irregular special moment resisting reinforced structures of different heights and also considering the soil-structure interaction for the same structures. For computing results, nonlinear static pushover analysis is applied. SAP2000 software application is considered for the analysis of the structures. It is noticed that the response reduction factor decreases with the increment in the height of the structure. The values of response reduction for the hard rock soil is higher than compared to that of the soft soil.