Present work describes an attempt to develop hybrid bio-composite material using Bombyx Silk & glass fiber reinforced in epoxy resin as matrix varying the orientation of silk fiber to the glass fiber at an angle of 90.˚ In medical industry weight is an important parameter that is considered widely in manufacturing of artificial limbs for physical disabled. Usually to support the person the structure needs enough strength to carry the weight of the person. The limb needs to be light in weight, so it should not affect the daily routine of the person. The structural member undergoes continuous cycles of compression and tension when the user is performing day to day activity. The procured materials were designed using COMSOL and different testing namely tensile, compression, flexure to be conducted on the samples