A subgrid-scale (SGS) model for compressible turbulent flows is presented in the combination of the mass-weighted filtering procedure with the theoretical results from a two-scale DIA. This model consists of the filtered equations for mass, momentum, and internal energy as well as the equation for the intensity of SGS density fluctuation. In this model, the effects of fluid compressibility appear through the intensity of SGS density fluctuation and the divergence of the grid-scale velocity. The model with the SGS density fluctuation neglected leads to the simplest compressible version of the Smagorinsky model.