As is well known, the binomial theorem is a classical mathematical relation that can be straightforwardly proved by induction or through a Taylor expansion, albeit it remains valid as long as [A,B]=0. In order to generalize such an important equation to cases where [A,B]≠0, an algebraic approach based on Cauchy’s integral theorem in conjunction with the Baker–Campbell–Hausdorff series is presented that allows a partial extension of the binomial theorem when the commutator [A,B]=c, where c is a constant. Some useful applications of the new proposed generalized binomial formula, such as energy eigenvalues and matrix elements of power, exponential, Gaussian, and arbitrary f(x̂) functions in the one-dimensional harmonic oscillator representation are given. The results here obtained prove to be consistent in comparison to other analytical methods.