Naive T cells and activated T cells express different adhesion molecules and patterns of migration. Naive T cells express CD62L. The research aims to assess the CD4+CD62L+ and CD8+CD62L+ profile of BALB/c mice model allergy on the sensitivity, the challenge and the gastrointestinal tract allergy phase after treatment with ethanol extract of Dioscorea alata L. (EEDA). An experimental study with post test only control group design using 63 BALB/c mice was divided into seven groups: control group (I) and treatment groups with the ethanol extract of D. alata L. tubers dose (0.00, 0.17, 2.01, 10.04) g · kg−1 bw (II-V); an antihistamine drug treatment (VI) and diosgenin treatment of 200 mg · kg−1 bw (VII). Treatment groups induced with ovalbumin i.p. on 15 d and 22 d, orally on 23 d to 30 d subsequently. Mice were sacrificed on (18, 25 and 31) d, the spleen was taken and isolated to measure CD4+CD62L+ and CD8+CD62L+ profile with flowcytometry. The results showed that EEDA dose (0.17, 10.04) g · kg−1 and drug on...