Magnetoelectric (ME) coupling by acoustic waveguide was developed. A very strong axial ME response was observed. The dependences of the sample size and the frequency of the ac field on the ME coupling were investigated. Several resonant points were observed in the frequency range applied (<50 kHz). Analysis shows that the standing waves transmitted in the waveguide were responsible for those resonances. And the resonant frequencies were closely influenced by the geometrical size of the waveguide. A resonant condition related to the size of the sample was obtained. The axial (or longitudinal) and transversal ME coefficients were observed to be up to 62 and 6 (V cm−1 Oe−1) at resonant points, respectively, indicating that the axial ME effect in this device was much higher than its transversal ones. A series of double-peak curves of axial ME coefficient versus magnetic field were observed. The significance of the double-peak curves was discussed.