We show that colliders can impose strong constraints on dark matter. We take an effective field theory approach where dark matter couples to quarks and gluons through high dimensional operators. We discuss limits on interactions of dark matter and hadronic matter from the ATLAS experiment at the Large Hadron Collider (LHC). For spin-independent scattering, the LHC limits are stronger than those from direct detection experiments for light WIMPs. For spin-dependent scattering, the LHC sets better limits over much of parameter space.