The chiral nature of many biomolecules would make highly sensitive enantiomer detection desirable. Utilizing the concept of optical chirality in nanophotonics and plasmonics we numerically analyze and compare different structures to meet the design criteria for increased sensitivity of such sensors. We demonstrate the differences between planar structures that are easily fabricated and three-dimensional designs that are capable of higher enhancement of optical chirality. Additionally, a sensor scheme combining both enantiomers of a chiral plasmonic nanostructure is proposed and investigated.