There were studies on uses of complementary and alternative medicine therapy to treat mental disorder like anxiety, depression, and adjustment disorder, whereas there was no effective method to treat such mental disorders. This study proposed a therapy from complementary and alternative medicine to treat mental disorder by through interactions of five senses between therapist and patient. In this method sounding a certain six voices play an important role in healing and recovery. By applying chaos theory, we investigated time series of six vocal sounds consisted of six syllables that have been used in the therapy. On the basis of the reconstructed phase space trajectory for the subject’s voices, we found chaos features in the six vocal sounds with correlation dimension of D2=3.02±0.8. Further, we studied the effect of spoken six voices on human status. A measure from RQA, diagonal length Lmax, was computed for the records of start and end of voices during consecutively spoken the voices lasting 1min long. The mean value of Lmax increased from 6.4 to 7.9, giving nearly 20% increase in the end of voice in relate to start. Wilcoxon test showed the significant changes in Lmax with p =0.019. Our results implied that the six vocal sounds induce a decrease of divergence in pulsation waves, leading to a formation of order out of chaos in human body. The proposed five sense therapy is a noninvasive intervention that can be used to reduce anxiety levels and improvement of mental health. First, we studied effects of speaking using scalp- EEG measurement. Chaos analysis of EEG showed a largely enhanced largest Lyapunov exponent (LLE) during the speaking. In addition, EEG power spectrum showed an increase over most frequencies. Second, we performed case studies on mental disorder using the therapy. Running power spectrum of EEG of patients indicated decreasing power at end of treatment, implying five senses therapy induced relaxed and lowered energy in central neural system. The results agreed with patient’s reports that there were considerable decline in anxiety and improvements in mood.