
Sarcomeres are the basic force generating units of striated muscles and consist of an interdigitating arrangement of actin and myosin filaments. While muscle contraction is usually triggered by neural signals, which eventually set myosin motors into motion, isolated sarcomeres can oscillate spontaneously between a contracted and a relaxed state. We analyze a model for sarcomere dynamics, which is based on a force-dependent detachment rate of myosin from actin. Our numerical bifurcation analysis of the spontaneous sarcomere dynamics reveals notably Hopf bifurcations, canard explosions, and gluing bifurcations. We discuss possible implications for experiments.
Sarcomeres, FOS: Physical sciences, Quantitative Biology - Tissues and Organs, Myosins, Models, Biological, Nonlinear Sciences - Adaptation and Self-Organizing Systems, Nonlinear Dynamics, FOS: Biological sciences, Animals, Muscle, Skeletal, Tissues and Organs (q-bio.TO), Adaptation and Self-Organizing Systems (nlin.AO)
Sarcomeres, FOS: Physical sciences, Quantitative Biology - Tissues and Organs, Myosins, Models, Biological, Nonlinear Sciences - Adaptation and Self-Organizing Systems, Nonlinear Dynamics, FOS: Biological sciences, Animals, Muscle, Skeletal, Tissues and Organs (q-bio.TO), Adaptation and Self-Organizing Systems (nlin.AO)
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 7 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
