
doi: 10.1056/nejmp058173
pmid: 16291979
The process of transformation of normal melanocytes into malignant melanoma requires the acquisition of genomic abnormalities. Dr. Paul Meltzer writes that tracking down the genetic changes in cancer has proved to be a powerful approach to the selection of therapeutic targets.
Proto-Oncogene Proteins B-raf, Genes, ras, Skin Neoplasms, Genome, Human, Mutation, Humans, Nucleic Acid Hybridization, DNA, Neoplasm, DNA Fingerprinting, Melanoma
Proto-Oncogene Proteins B-raf, Genes, ras, Skin Neoplasms, Genome, Human, Mutation, Humans, Nucleic Acid Hybridization, DNA, Neoplasm, DNA Fingerprinting, Melanoma
| citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 14 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
