Metabolism, Gliomas, andIDH1

descriptionPublicationkeyboard_double_arrow_right Article 25 Mar 2010 English Publisher:Massachusetts Medical SocietyJournal:New England Journal of Medicine, volume 362, pages 1,144-1,145 (issn: 0028-4793, eissn: 1533-4406,

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Authors: Smeitink, J.A.M.; Smeitink, J.A.M.;

doi: 10.1056/nejmcibr0912922

pmid: 20335593

handle: https://repository.ubn.ru.nl/handle/2066/87714 , 2066/87714

Metabolism, Gliomas, andIDH1

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Abstract

A mutation in IDH1, which encodes an isocitrate dehydrogenase, is associated with susceptibility to glioma. This mutation results in an acquired enzyme activity that points to a potential biomarker of the mutant tumor.

Related Organizations

Radboud University Nijmegen Medical Centre
Netherlands
Radboud University Nijmegen
Netherlands

Keywords

Genetic Markers, Isocitrates, Brain Neoplasms, Glioma, Prognosis, Isocitrate Dehydrogenase, Glutarates, Mutation, Humans, Ketoglutaric Acids, Mutant Proteins, IGMD 8: Mitochondrial medicine, Metabolism, Inborn Errors

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