Molecular Mimicry in Multiple Sclerosis

descriptionPublicationkeyboard_double_arrow_right Article 10 Jul 2003 English Publisher:Massachusetts Medical SocietyJournal:New England Journal of Medicine, volume 349, pages 185-186 (issn: 0028-4793, eissn: 1533-4406,

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Authors: Wekerle, H.; Hohlfeld, R.;

doi: 10.1056/nejmcibr035136

pmid: 12853593

handle: 11858/00-001M-0000-0012-2310-F

Molecular Mimicry in Multiple Sclerosis

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Abstract

Molecular mimicry is a model in which foreign antigens are sufficiently similar to native antigens to trigger an autoimmune response. A study involving the specificity of a T-cell receptor derived from a patient with multiple sclerosis indicates that molecular mimicry extends to complexes of proteins — a finding with implications for therapy.

Related Organizations

Max Planck Society
Germany
Max Planck Institute for Biological Intelligence
Germany

Keywords

Herpesvirus 4, Human, Multiple Sclerosis, Receptors, Antigen, T-Cell, alpha-beta, Molecular Mimicry, Mice, Transgenic, HLA-DR Antigens, Cell Line, Mice, Animals, Humans

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