Hazards of Hazard Ratios — Deviations from Model Assumptions in Immunotherapy

descriptionPublicationkeyboard_double_arrow_right Article 22 Mar 2018 English Publisher:Massachusetts Medical SocietyJournal:New England Journal of Medicine, volume 378, pages 1,158-1,159 (issn: 0028-4793, eissn: 1533-4406,

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Authors: Brian M. Alexander; Jonathan D. Schoenfeld; Lorenzo Trippa;

doi: 10.1056/nejmc1716612

pmid: 29562148

Hazards of Hazard Ratios — Deviations from Model Assumptions in Immunotherapy

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Abstract

Look Beyond Hazard Ratios Many trials are based on the proportional-hazards assumption that an event is equally likely in different treatment groups over time and deviations are related to the intervention. Full Kaplan–Meier estimates from earlier trials may be more informative than summary statistics.

Related Organizations

Dana-Farber Cancer Institute
United States
Harvard University
United States

Keywords

Humans, Immunotherapy, Kaplan-Meier Estimate, Survival Analysis, Disease-Free Survival, Proportional Hazards Models

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