Purinergic Signaling during Inflammation

descriptionPublicationkeyboard_double_arrow_right Article 13 Dec 2012 English Publisher:Massachusetts Medical SocietyJournal:New England Journal of Medicine, volume 368, pages 1,260-1,260 (issn: 0028-4793, eissn: 1533-4406,

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Authors: Holger K, Eltzschig; Michail V, Sitkovsky; Simon C, Robson;

doi: 10.1056/nejmc1300259 , 10.1056/nejmra1205750

pmid: 23534573 , 23234515 , 23534574

pmc: PMC3675791

Purinergic Signaling during Inflammation

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Abstract

Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for these nucleosides are emerging as therapeutic targets in a number of inflammatory and autoimmune diseases.

Related Organizations

Northwestern University
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University of Colorado Denver
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University of Colorado Cancer Center
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Keywords

Blood Platelets, Inflammation, Neoplasms, Acute Lung Injury, Humans, Immunotherapy, Inflammatory Bowel Diseases, Purine Nucleotides, Signal Transduction

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