In their review article, Rahman and Isenberg (Feb. 28 issue)1 emphasize the role of anti–double-stranded DNA antibodies in the pathogenesis of systemic lupus erythematosus. Such antibodies also occur, however, in 23 to 64% of patients with type 1 autoimmune hepatitis, depending on the assay used.2 Interestingly, 36% of patients with type 1 autoimmune hepatitis and antibodies against double-stranded DNA have the HLA allele DR3, which is a genetic risk factor in both systemic lupus erythematosus and type 1 autoimmune hepatitis.3 However, there is no evidence of a pathogenic role of anti–double-stranded DNA antibodies in type 1 autoimmune hepatitis.