Miscellaneous Agents Hormones. The steroid hormones were among the first agents used in cancer therapy. The uniquely specific stimulus-response relations causing proliferation of the tissues in secondary sex organs naturally led to attempts at surgical removal of gonadal sources of estrogen in breast cancer168 and androgen in cases of prostatic carcinoma.169 Administration of exogenous sex hormones followed naturally. Hormonal treatment of breast carcinoma has shown a gratifying number of beneficial responses and, having recently been reviewed in this series,170 will not be discussed at this time. Brief mention of the progestational agents, however, is in order. These agents have been . . .