THE syndrome of low serum gamma globulin in the presence of relatively normal quantities of the other protein factors has recently been described in children, but has not heretofore been observed in adults. The first case of "agammaglobulinemia" was reported by Bruton1 in a boy who, between the ages of four and a half and eight years, had 18 bouts of sepsis with 8 different types of pneumococci isolated, 5 episodes of otitis media, and 3 attacks of epidemic parotitis. Prophylactic antibacterial therapy was not always successful in preventing reinfection. After autogenous pneumococcal vaccine, typhoid vaccine and diphtheria immunization, no . . .