Solid-Phase Synthesis of CD40L Mimetics
Copyright policy )Solid-Phase Synthesis of CD40L Mimetics
The C3-symmetric molecule has been previously shown to mimic CD40 ligand (CD40L) homotrimers and to display effector functions. This molecule consists of a cyclic hexapeptide core containing the repetition of the D-Ala-L-Lys motif. The side chains of the lysine residues have been modified by appending the CD40L-derived sequence 143Lys-Gly-Tyr-Tyr146 via a 6-aminohexanoic acid residue as a spacer. The present report describes a general solid-phase synthesis approach to and related trimeric architectures. In addition, their CD40 binding properties as well as their effector functions have been evaluated.
Molecular Structure, Cell Line, Tumor, CD40 Ligand, Molecular Mimicry, Combinatorial Chemistry Techniques, Humans, Apoptosis, Chromatography, High Pressure Liquid, Protein Binding
Molecular Structure, Cell Line, Tumor, CD40 Ligand, Molecular Mimicry, Combinatorial Chemistry Techniques, Humans, Apoptosis, Chromatography, High Pressure Liquid, Protein Binding
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