Welcome to the latest issue of Seminars in Thrombosis and Hemostasis (STH) published under the “banner” of “Editorial Compilation,” this being the twelfth such issue. Although Seminars in Thrombosis and Hemostasis is historically a theme-driven publication, ongoing opportunities emerge to disseminate wide-ranging contributions of current interest or controversy, and which do not straightforwardly suit an ongoing themed issue. We also require a medium for enabling publication of accepted peer reviewed “unsolicited” manuscripts, as well as additional contributions from our Eberhard F. Mammen Young Investigator Award winners. As it is now standard for this compilation series, the current issue contains a mixture of articles that comprises the above elements, as well as broadly fitting within the standard themes of “thrombosis” and “bleeding.”