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Seminars in Neurology
Article . 2019 . Peer-reviewed
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Vascular Cognitive Disorder

Authors: Paradise, Matt; Sachdev, PS;

Vascular Cognitive Disorder

Abstract

AbstractThe term vascular cognitive disorder (VCD) refers to a heterogeneous group of disorders in which the primary feature is cognitive impairment attributable to cerebrovascular disease (CVD). This includes not only vascular dementia (VaD) but also cognitive impairment of insufficient severity to meet diagnostic criteria for dementia. VCD is recognized as the second most common cause of dementia after Alzheimer's disease (AD), but prevalence rates vary widely according to the diagnostic criteria employed. There have been recent attempts to standardize diagnostic criteria. VCD incorporates a range of neuropathological mechanisms including poststroke impairment, small and large vessel disease, and cases of mixed-pathology, with CVD interacting with AD and other neuropathologies. Recent neuroimaging data have improved our understanding of the etiology of VCD. Symptomatic treatments for VaD have modest benefit and there is increased focus on the primary and secondary preventative benefits of vascular risk factor control.

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Keywords

Aging, Cerebrovascular, 610, 32 Biomedical and Clinical Sciences, anzsrc-for: 1109 Neurosciences, Neurodegenerative, Alzheimer's Disease, Cardiovascular, anzsrc-for: 1103 Clinical Sciences, anzsrc-for: 32 Biomedical and Clinical Sciences, Vascular, Vascular Cognitive Impairment/Dementia, 616, Acquired Cognitive Impairment, 2.1 Biological and endogenous factors, Humans, Cognitive Dysfunction, 3202 Clinical Sciences, Alzheimer's Disease Related Dementias (ADRD), Dementia, Vascular, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, 4.1 Discovery and preclinical testing of markers and technologies, Cerebral Small Vessel Diseases, 3209 Neurosciences, Neurological, anzsrc-for: 3209 Neurosciences, Dementia, anzsrc-for: 3202 Clinical Sciences, Intracranial Arterial Diseases

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    popularity
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    Top 10%
    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
27
Top 10%
Top 10%
Top 10%
Green