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Plasmin inactivation in Plasma

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1976Publisher:Georg Thieme Verlag KGJournal:Thrombosis and Haemostasis, volume 35, pages 643-650 (issn: 0340-6245, eissn: 2567-689X,

Authors: Vreeken J; E. M Haselager; Th. M Goote;

doi: 10.1055/s-0038-1647963

pmid: 62411

Plasmin inactivation in Plasma

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Abstract

SummaryInhibition and inactivation of plasmin is ascribed to α2-macroglobulin, α1-antitrypsin and c1-esterase inhibitor. In an “overall” inactivation test of plasmin in plasma, which comes perhaps closest to rapid inactivation of plasmin in the circulating blood, we only found a correlation between the immunological concentration of α2-macroglobulin and the plasmin-inac-tivating capacity of the plasma, but no correlation with the immunological concentration of the other inhibitors mentioned. Therefore, α2-macroglobulin seems to be the most important plasmin inhibitor in relation to thrombosis.

Keywords

alpha 1-Antitrypsin, Esterases, Humans, alpha-Macroglobulins, Blood Coagulation Tests, Fibrinolysin, Enzyme Inhibitors

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