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Demethoxycurcumin and its Semisynthetic Analogues as Antitubercular Agents

descriptionPublicationkeyboard_double_arrow_right Article 07 Nov 2008 English Publisher:Georg Thieme Verlag KGJournal:Planta Medica, volume 74, pages 1,828-1,831 (issn: 0032-0943, eissn: 1439-0221,

Authors: Arvind S. Negi; Shweta Ojha; Dinesh Kumar Agrawal; Karuna Shanker; Richa Tiwari; Anil K. Gupta; Suman Preet Singh Khanuja; +3 Authors

doi: 10.1055/s-0028-1088335

pmid: 18991209

Demethoxycurcumin and its Semisynthetic Analogues as Antitubercular Agents

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Abstract

Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H (37)Rv strain at 200 microg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 microg/mL. H (37)Rv:Mycobacterium tuberculosis H (37)Rv strain MIC:minimum inhibitory concentration.

Related Organizations

Central Institute of Medicinal and Aromatic Plants
India

Keywords

Curcuma, Curcumin, Molecular Structure, Diarylheptanoids, Plant Extracts, Antitubercular Agents, Mycobacterium tuberculosis, Rhizome

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