The therapeutic objective of parenteral nutrition, as well as any other pharmacological treatment, must be organized for and focused on the patient, to obtain outcomes associated with an improvement in health status and quality of life. On this basis, the present article starts with a view of quality improvement in health care, identifying the structure, process and outcome paradigm for drug therapy and parenteral nutrition elements of quality assessment, as well as strategies for quality improvement will be described. A model of the organization assigned to parenteral nutrition care is proposed. In the future, computerized programs of parenteral nutrition may increase the risk of uncoordinated and fragmented care. The programs must improve health care of patient by exposing caregivers to the full alternatives of decisions with clinical and therapeutic data on patient individual.