Neutrophil alloantigens
Copyright policy )Neutrophil alloantigens
Antibodies to neutrophil antigens can cause neonatal alloimmune neutropenia, autoimmune neutropenia, febrile transfusion reactions, and transfusion-related acute lung injury. Several neutrophil antigen systems have been described serologically, but only the human neutrophil antigen-1 (HNA-1) or NA and HNA-2 or NB systems have been well characterized biochemically and molecularly. HNA-1 antigens are located on FcgammaRIIIb, CD16. HNA-2 antigens are located on 58- to 64-Kd glycoprotein, CD177, and are encoded by a gene on chromosome 19 that belongs to the Ly-6 family. The function of the CD177 is not known, but the CD177 gene is highly homologous to a gene overexpressed in neutrophils from patients with polycythemia rubra vera called PRV-1. New polymorphisms in these antigen systems are still being described, but the complete understanding of these neutrophil antigen systems has been slow because of the complexity of these genes.
- National Institutes of Health United States
Isoantigens, Membrane Glycoproteins, Neutropenia, Polymorphism, Genetic, Neutrophils, Receptors, IgG, Mutation, Missense, Antibodies, Monoclonal, Gene Expression, Genetic Variation, Receptors, Cell Surface, GPI-Linked Proteins, Amino Acid Substitution, CD18 Antigens, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Terminology as Topic, Humans, Forecasting, Granulocytes
Isoantigens, Membrane Glycoproteins, Neutropenia, Polymorphism, Genetic, Neutrophils, Receptors, IgG, Mutation, Missense, Antibodies, Monoclonal, Gene Expression, Genetic Variation, Receptors, Cell Surface, GPI-Linked Proteins, Amino Acid Substitution, CD18 Antigens, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Terminology as Topic, Humans, Forecasting, Granulocytes
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