Cardiopulmonary bypass (CPB) systems have evolved from futuristic visions of surgical pioneers to a safe and efficient tool in the therapy of treatment of cardiac disorders. There are many significant differences in the physiology between neonates and adult patients. There are currently very few congenital cardiac malformations that cannot be addressed effectively with surgical therapy. Yet, the necessity of CPB in the repair of these patients can still result in significant morbidity. A clearer understanding of the effects of CPB, hypothermia, and circulatory arrest is evolving and there is a considerable amount of research in these areas. It seems likely that modification of current CPB systems, minimization of exposure, and surgical techniques to avoid or limit the adverse effects may reduce mortality and morbidity in the future. The problems faced in these complex patients and procedures require that infant and neonatal cardiac surgery be performed in specialized centers with a multidisciplinary approach and specialized personnel. Future improvements in technology will likely result in improved long term outcome for children with congenital cardiac disease. Copyright 2000 by W.B. Saunders Company