Abstract Postoperative wound infections are one of the most common nosocomial infections in surgical patients and the third most common nosocomial infection in all hospitalized patients. Surgical wound infections commonly increase the need for antibiotics and increase the length of stay and hospital costs. Although this subject has been discussed frequently in the adult literature, fewer than 10 articles exist on the subject in the pediatric patient population, despite the rate of surgical wound infection, which ranges from 3 to 20 percent. Surgical site infections are potentially preventable complications that increase hospital costs as well as patient morbidity and discomfort. Recognizing the patient who is at high risk for a surgical site infection and providing appropriate antibiotic prophylaxis to those patients is an important step in decreasing surgical site infections. This article discusses the risks of surgical site infection specific to pediatric surgical procedures, as well as appropriate antibiotic prophylaxis and treatment. Copyright © 2001 by W.B. Saunders Company