Biomimesis has become the objective of the reconstructive strategies after chest wall resections for primary or secondary tumors. Biomimesis is pursued by respecting the anatomy, preserving function, selecting adequate reconstructive materials, and integrating multidisciplinary efforts for complex reconstructions. Elements of novelty in the clinical practice are represented by the introduction of the principles of video-assisted thoracic surgery to resect chest wall tumors and the increasingly frequent resort to either new materials or revised concepts of time-honored ones for chest wall reconstruction. Experimental investigation seems to outline interesting perspectives for materials destined to reconstruction after either partial or full-thickness resections for recurrent chest wall tumors.