Spinal infections may be local manifestations of systemic diseases,concomitantwithinfectionsinotherpartsofthe central nervous system, or be caused by direct spread from extraspinal sources. Patient demographics and their immune status play an important role when formulating the differential diagnosis of lesions affecting the discs and vertebral bodies. In this article, we describe the clinical manifestations, imaging findings, diagnostic criteria, and treatment and prognosis of spinal infections. Many pathogens can cause spondylitis as well as meningitis/myelitis and thus both entitiesareaddressedhere.Diseasesprimarilyaffectingthespinal cord and its coverings are discussed separately from those primarily involving the bones, paraspinal regions, and epidural space.