Fibrillary Glomerulonephritis Presenting as Rapidly Progressive Glomerulonephritis
Copyright policy )Fibrillary Glomerulonephritis Presenting as Rapidly Progressive Glomerulonephritis
Fibrillary glomerulonephritis (GN) is an uncommon cause of rapidly progressive kidney failure. We report a case of rapidly progressive kidney failure with kidney biopsy showing crescentic GN on light microscopy and immunofluorescence showing linear/globular glomerular basement membrane (GBM) staining for immunoglobulin G and C3, consistent with anti-GBM disease. However, electron microscopy showed fibrillary deposits in the GBM, suggesting a diagnosis of fibrillary GN. As exemplified by this case, it is important to consider fibrillary GN in the differential diagnosis of crescentic GN with linear immunoglobulin G deposits within the GBM. Electron microscopy is crucial to make this diagnosis.
- Johns Hopkins University United States
Time Factors, Biopsy, Needle, Kidney Glomerulus, Middle Aged, Immunohistochemistry, Diagnosis, Differential, Glomerulonephritis, Pulse Therapy, Drug, Immunoglobulin G, Disease Progression, Humans, Female, Infusions, Intravenous, Cyclophosphamide, Immunosuppressive Agents
Time Factors, Biopsy, Needle, Kidney Glomerulus, Middle Aged, Immunohistochemistry, Diagnosis, Differential, Glomerulonephritis, Pulse Therapy, Drug, Immunoglobulin G, Disease Progression, Humans, Female, Infusions, Intravenous, Cyclophosphamide, Immunosuppressive Agents
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