The Physician Quality Reporting Initiative (PQRI) is a voluntary program in which Medicare encourages eligible physicians in the United States to report on specific quality measures. This article is a case study of the implementation of PQRI reporting by Kidney Associates, a nephrology practice in Houston, TX. After reviewing and discussing 74 potential measures, the group narrowed the selection to 5 and chose 1 office measure and 2 dialysis measures. PQRI reporting was established through an Encounter Note template that forced a required entry for whether a patient was diabetic. For each diabetic, blood pressures were entered in the template and appropriate G-codes were created, which were then selected and linked with the diabetes International Classification of Diseases, Ninth Revision code and electronically submitted for billing. The dialysis measures were automatically selected from the urea reduction rate and hematocrit (hemoglobin x 3) measures that were received for each patient on a regular basis from a large dialysis chain. Software was developed to parse these data, evaluate them, and generate the appropriate G-codes. At the end of the billing cycle, these data were exported through a standard spreadsheet formatting along with the billing G codes, and claims were submitted. The system was cost-effective to implement, required minimal education, and achieved 100% cooperation through feedback education and rapid correction of systems issues. Kidney Associates was able to show that PQRI reporting is easy to implement with minimal expense and staff labor. Sharing these methods with other practices should facilitate the implementation of efficient reporting systems.