A lipoma is the most common soft tissue tumour. This benign mass can arise at any location in the body containing adipose tissue, but particularly in subcutaneous tissues of the upper half of the body and proximal extremities. Primary intracardiac tumours, including lipomas are well documented. Primary tumour of the major central veins arise most frequently from the inferior vena cava, the right brachiocefalic vein and the superior vena cava, but are very unusual. Primary tumours of the lower leg veins are rare but usually malignant lesions, leiomyosarcoma being the most frequent. Benign forms mainly represented by leiomyomas are exceptional. Only two cases of lipoma arising from major leg veins have been previously reported. We present a case of an intraluminal lipoma of the external iliac vein and common femoral vein.