Implantation is a highly co-ordinated event that involves both embryonic and endometrial participation. The endometrium expresses a sophisticated repertoire of proteins during the menstrual cycle many of which help to define a period of receptivity collectively known as the 'window of implantation'. Many of these factors, which are temporally aligned with this window, are now seen as chemical messengers that are recognized by the embryo and facilitate embryonic growth and differentiation. The use of such proteins as biomarkers has also advanced our understanding of the implantation process and may identify women with implantation failure and infertility. While the study of endometrial receptivity is still evolving, the field is growing rapidly and will probably enhance our ability to diagnose and treat couples with infertility, especially in the arena of assisted reproductive technologies (ART).