Pharyngocutaneous fistulization is a dreaded and devastating complication of laryngectomy. Although the specific risk factors are controversial, a history of prior radiation therapy has generally been accepted to be a major risk factor for developing this complication. We present a case of a postlaryngectomy pharyngocutaneous fistula developing in a previously irradiated patient that was successfully managed by incorporating fibrin glue into the surgical closure. We also discuss the underlying theoretical basis for this approach by reviewing the relevant literature.