Classical activation of macrophages and vardenafil

descriptionPublicationkeyboard_double_arrow_right Article 22 May 2017 United Kingdom English Publisher:Portland Press Ltd.Journal:Clinical Science, volume 131, pages 1,141-1,145 (issn: 0143-5221, eissn: 1470-8736,

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Authors: Muimo, R.;

doi: 10.1042/cs20170137

pmid: 28533270

Classical activation of macrophages and vardenafil

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Abstract

Inhibitors of phosphodiesterase 5 (PDE5) – sildenafil citrate (Viagra; Pfizer) and vardenafil hydrochloride (Levitra; Bayer/GlaxoSmithKline) – approved for the treatment of erectile dysfunction and pulmonary arterial hypertension also rescue the loss of cystic fibrosis (CF) chloride channel function and the mislocalization of F508del-CFTR in affected tissues in CF. Can PDE5 inhibitors provide a therapeutic strategy which combines ability to correct the basic ion transport defect and to control de-regulated lung inflammation in CF?

Country

United Kingdom

Related Organizations

University of Sheffield
United Kingdom
White Rose Consortium: University of Leeds; University of Sheffield; University of York
United Kingdom

Keywords

Immunology & Inflammation, Molecular Interactions, Macrophages, Imidazoles, Cystic Fibrosis Transmembrane Conductance Regulator, Molecular Bases of Health & Disease, Piperazines, Vardenafil Dihydrochloride, Humans, Sulfones

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