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A Monoclonal Antibody for Immunopurification of Human Renin

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1981 English Publisher:Portland Press Ltd.Journal:Clinical Science, volume 61, pages 239s-240s (issn: 0144-9664,

Authors: Bernard Pau; F X Galen; C. Devaux; Pierre Corvol; Joël Ménard; Florent Soubrier; D Simon;

doi: 10.1042/cs061239s

pmid: 6797775

A Monoclonal Antibody for Immunopurification of Human Renin

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Abstract

1. A mouse hybridoma secreting an antibody directed against human renin was obtained by fusion of spleen cells with NS 1 myeloma cells. This monoclonal antibody recognizes human and monkey renins but neither hog nor mouse renins nor the acid proteinase cathepsin D. 2. Monoclonal antibody was coupled to Sepharose 4 B. The immunoadsorbent thus obtained was very efficient in purifying both active and inactive human renin from renal or extrarenal sources. 3. Renin enrichment up to 3500-fold was obtained in a single step.

Related Organizations

French Institute of Health and Medical Research
France

Keywords

Mice, Inbred BALB C, Hybridomas, Swine, Antibodies, Monoclonal, Haplorhini, Mice, Antibody Specificity, Renin, Animals, Humans, Immunosorbent Techniques

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	12
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average