Characterization of Immunoreactive Angiotensin in Canine Cerebrospinal Fluid as Des-Asp1-Angiotensin II

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1978 English Publisher:Portland Press Ltd.Journal:Clinical Science, volume 54, pages 147-151 (issn: 0301-0538,

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Authors: J S, Hutchinsón; J, Csicsmann; P I, Korner; C I, Johnston;

doi: 10.1042/cs0540147

pmid: 620503

Characterization of Immunoreactive Angiotensin in Canine Cerebrospinal Fluid as Des-Asp1-Angiotensin II

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Abstract

1. Immunoreactive angiotensin II was measured in cerebrospinal fluid of four normal dogs. 2. The migration of this immunoreactive angiotensin II on polyacrylamide-slab gel electrophoresis was identical with the migration of the heptapeptide, Des-Asp1-angiotensin II, in each case. 3. The biological activity of the material from canine cerebrospinal fluid in a pressor bioassay was similar to that of Des-Asp1-angiotensin II. 4. The pressor activity of the canine material was abolished by treating the pressor bioassay rat with a competitive antagonistic analogue, Sar1-Ala8-angiotensin II. 5. The results suggest that the biologically active immunoreactive angiotensin II present in normal canine cerebrospinal fluid is composed mainly of the heptapeptide fragment of angiotensin II, Des-Asp1-angiotensin II.

Keywords

Dogs, Angiotensin II, Animals, Blood Pressure, Electrophoresis, Polyacrylamide Gel, Angiotensin III, Saralasin, Rats

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