STARs in the CNS
Copyright policy )STARs in the CNS
STAR (signal transduction and activation of RNA) proteins regulate splicing of target genes that have roles in neural connectivity, survival and myelination in the vertebrate nervous system. These regulated splicing targets include mRNAs such as the Neurexins (Nrxn), SMN2 (survival of motor neuron) and MAG (myelin-associated glycoprotein). Recent work has made it possible to identify and validate STAR protein splicing targets in vivo by using genetically modified mouse models. In this review, we will discuss the importance of STAR protein splicing targets in the CNS (central nervous system).
- University of Montpellier France
- University of Montpellier France
- Newcastle University United Kingdom
- University of Newcastle Australia Australia
- French National Centre for Scientific Research France
Central Nervous System, Cell Adhesion Molecules, Neuronal, RNA Splicing, Calcium-Binding Proteins, [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, RNA-Binding Proteins, Nerve Tissue Proteins, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Survival of Motor Neuron 2 Protein, Myelin-Associated Glycoprotein, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.BID.SPT] Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Animals, Humans, RNA, Messenger, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Neural Cell Adhesion Molecules, Phylogeny
Central Nervous System, Cell Adhesion Molecules, Neuronal, RNA Splicing, Calcium-Binding Proteins, [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, RNA-Binding Proteins, Nerve Tissue Proteins, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Survival of Motor Neuron 2 Protein, Myelin-Associated Glycoprotein, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.BID.SPT] Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Animals, Humans, RNA, Messenger, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Neural Cell Adhesion Molecules, Phylogeny
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