The spindle assembly checkpoint: progress and persistent puzzles

descriptionPublicationkeyboard_double_arrow_right Article 20 Nov 2013 English Publisher:Portland Press Ltd.Journal:Biochemical Society Transactions, volume 41, pages 1,755-1,760 (issn: 0300-5127, eissn: 1470-8752,

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Authors: Hauf, S.;

doi: 10.1042/bst20130240

pmid: 24256287

handle: 21.11116/0000-000A-64AA-6

The spindle assembly checkpoint: progress and persistent puzzles

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Abstract

The spindle assembly checkpoint is a conserved mitotic signalling pathway that ensures the equal segregation of chromosomes to daughter cells. Despite intensive work in many model organisms, key features of this safety mechanism remain unexplained. In the present review, I briefly summarize advances made in the last few years, and then focus on unexplored corners of this signalling pathway.

Related Organizations

Max Planck Society
Germany

Keywords

Chromosome Segregation, Schizosaccharomyces, Humans, Mitosis, Spindle Apparatus, Signal Transduction

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