Palmitoylation of influenza virus proteins

descriptionPublicationkeyboard_double_arrow_right Article 29 Jan 2013 English Publisher:Portland Press Ltd.Journal:Biochemical Society Transactions, volume 41, pages 50-55 (issn: 0300-5127, eissn: 1470-8752,

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Authors: Michael, Veit; Marina V, Serebryakova; Larisa V, Kordyukova;

doi: 10.1042/bst20120210

pmid: 23356257

Palmitoylation of influenza virus proteins

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Abstract

Influenza viruses contain two palmitoylated (S-acylated) proteins: the major spike protein HA (haemagglutinin) and the proton-channel M2. The present review describes the fundamental biochemistry of palmitoylation of HA: the location of palmitoylation sites and the fatty acid species bound to HA. Finally, the functional consequences of palmitoylation of HA and M2 are discussed regarding association with membrane rafts, entry of viruses into target cells by HA-mediated membrane fusion as well as the release of newly assembled virus particles from infected cells.

Related Organizations

Lomonosov Moscow State University
Russian Federation
Freie Universität Berlin
Germany

Keywords

Acylation, Lipoylation, Molecular Sequence Data, Palmitic Acid, Hemagglutinin Glycoproteins, Influenza Virus, Influenza B virus, Viral Proteins, Influenza A virus, Biocatalysis, Amino Acid Sequence, Signal Transduction

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