ESCRTs and human disease

descriptionPublicationkeyboard_double_arrow_right Article 20 Jan 2009 English Publisher:Portland Press Ltd.Journal:Biochemical Society Transactions, volume 37, pages 167-172 (issn: 0300-5127, eissn: 1470-8752,

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Authors: Suraj, Saksena; Scott D, Emr;

doi: 10.1042/bst0370167

pmid: 19143624

ESCRTs and human disease

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Abstract

The ESCRT (endosomal sorting complex required for transport) machinery plays a critical role in receptor down-regulation, retroviral budding, and other normal and pathological processes. The ESCRT components are conserved in all five major subgroups of eukaryotes. This review summarizes the growing number of links identified between ESCRT-mediated protein sorting in the MVB (multivesicular body) pathway and various human diseases.

Related Organizations

Cornell University
United States

Keywords

Protein Transport, Multiprotein Complexes, Cell Cycle, Down-Regulation, Humans, Disease, Endosomes

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