Neurotoxicity of tryptophan metabolites

descriptionPublicationkeyboard_double_arrow_right Article 25 Oct 2007 English Publisher:Portland Press Ltd.Journal:Biochemical Society Transactions, volume 35, pages 1,287-1,289 (issn: 0300-5127, eissn: 1470-8752,

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Authors: A J, Smith; T W, Stone; R A, Smith;

doi: 10.1042/bst0351287

pmid: 17956331

Neurotoxicity of tryptophan metabolites

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Abstract

The metabolism of tryptophan by the kynurenine pathway leads to the production of several neurotoxic compounds, some of which have been associated with neurological disorders. Recent investigation of some relevant compounds in this pathway has provided further evidence of their neurotoxicity.

Related Organizations

Institute of Biomedical Science
United Kingdom
University of Glasgow
United Kingdom

Keywords

Mice, Tryptophan, Animals, Brain, Humans

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