Programmed −1 ribosomal frameshifting in the SARS coronavirus
Copyright policy )Programmed −1 ribosomal frameshifting in the SARS coronavirus
Programmed −1 ribosomal frameshifting is an alternate mechanism of translation used by coronavirus to synthesize replication proteins encoded by two overlapping open reading frames. For some coronaviruses, the mRNA cis-acting stimulatory structures involved in this process have been characterized, but their precise contribution to ribosomal frameshifting is not completely understood. Recently, a novel coronavirus was identified as the causative agent of the severe acute respiratory syndrome. This review describes the mRNA motifs involved in programmed −1 ribosomal frameshifting in this virus.
- University of Cambridge United Kingdom
- Cambridge University Hospitals NHS Foundation Trust United Kingdom
- Addenbrooke's Hospital United Kingdom
Base Sequence, Molecular Sequence Data, Genome, Viral, Open Reading Frames, Severe acute respiratory syndrome-related coronavirus, Nucleic Acid Conformation, Amino Acid Sequence, Frameshift Mutation, Ribosomes, Signal Transduction
Base Sequence, Molecular Sequence Data, Genome, Viral, Open Reading Frames, Severe acute respiratory syndrome-related coronavirus, Nucleic Acid Conformation, Amino Acid Sequence, Frameshift Mutation, Ribosomes, Signal Transduction
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