The anaphase-promoting complex (APC): the sum of its parts?
Copyright policy )The anaphase-promoting complex (APC): the sum of its parts?
The APC (anaphase-promoting complex) is a multisubunit E3 ubiquitin ligase that targets cell-cycle-related proteins for degradation by the 26 S proteasome. The APC contains at least 13 subunits and is regulated by the binding of co-activator proteins and by phosphorylation. It is not known why the APC contains 13 subunits when many other ubiquitin ligases are small single-subunit enzymes. In the present study, the structures and functions of individual APC subunits are discussed. By dissecting the roles of its parts, we hope to gain insight into the mechanism of the intact APC.
- Institute of Cancer Research United Kingdom
Saccharomyces cerevisiae Proteins, Catalytic Domain, Amino Acid Motifs, Cell Cycle, Ubiquitin-Protein Ligase Complexes, Saccharomyces cerevisiae, Phosphorylation, Models, Biological, Anaphase-Promoting Complex-Cyclosome, Protein Structure, Tertiary
Saccharomyces cerevisiae Proteins, Catalytic Domain, Amino Acid Motifs, Cell Cycle, Ubiquitin-Protein Ligase Complexes, Saccharomyces cerevisiae, Phosphorylation, Models, Biological, Anaphase-Promoting Complex-Cyclosome, Protein Structure, Tertiary
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).22 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!