B-cell development and antigen receptor signalling

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2002 English Publisher:Portland Press Ltd.Journal:Biochemical Society Transactions, volume 30, pages 812-815 (issn: 0300-5127, eissn: 1470-8752,

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Authors: M, Turner;

doi: 10.1042/bst0300812

pmid: 12196204

B-cell development and antigen receptor signalling

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Abstract

B-cell development and function requires the products of the Vav family of genes. Vav proteins act as key components of the antigen receptor signal transduction machinery by integration of signals that control the cell cycle, differentiation and apoptosis. At the molecular level, Vav proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux.

Related Organizations

Babraham Institute
United Kingdom

Keywords

Mice, Knockout, Oncogene Proteins, B-Lymphocytes, Receptors, Antigen, B-Cell, Cell Cycle Proteins, Mice, Proto-Oncogene Proteins, Animals, Humans, Proto-Oncogene Proteins c-vav, Signal Transduction

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