The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?
Copyright policy )The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?
Phosphoinositide signals regulate cell proliferation, differentiation, cytoskeletal rearrangement and intracellular trafficking. Hydrolysis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3, by inositol polyphosphate 5-phosphatases regulates synaptic vesicle recycling (synaptojanin-1), hematopoietic cell function [SHIP1(SH2-containing inositol polyphosphate 5-phosphatase-1)], renal cell function [OCRL (oculocerebrorenal syndrome of Lowe)] and insulin signalling (SHIP2). We present here a detailed review of the characteristics of the ten mammalian 5-phosphatases. Knockout mouse phenotypes and underexpression studies are associated with significant phenotypic changes, indicating non-redundant roles, despite, in many cases, overlapping substrate specificity and tissue expression. The extraordinary complexity in the control of phosphoinositide signalling continues to be revealed.
- Monash University Australia
- Monash University, Clayton campus Australia
Inositol Polyphosphate 5-Phosphatases, Models, Biological, Phosphoric Monoester Hydrolases, Protein Structure, Tertiary, Isoenzymes, Phosphatidylinositol 3-Kinases, Oculocerebrorenal Syndrome, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Animals, Humans, Insulin, Synaptic Vesicles
Inositol Polyphosphate 5-Phosphatases, Models, Biological, Phosphoric Monoester Hydrolases, Protein Structure, Tertiary, Isoenzymes, Phosphatidylinositol 3-Kinases, Oculocerebrorenal Syndrome, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Animals, Humans, Insulin, Synaptic Vesicles
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