Identification of hub genes related to prognosis in glioma
Copyright policy )Identification of hub genes related to prognosis in glioma
Abstract Glioma, a common malignant tumor of the central nervous system, has high invasiveness. The objective of the present study was to identify genes playing an important role in the development of glioma and to reveal their potential research value. Conjoint analysis on the GSE16011 dataset in the Gene Expression Omnibus (GEO) database and the ‘Messenger RNA Expression Microarray of Diffuse Gliomas and Controls’ dataset and ‘RNA sequencing of Diffuse Gliomas’ dataset in the Chinese Glioma Genome Atlas (CGGA) database is carried out in the study. The weighted correlation network analysis (WGCNA) was used to carry out co-expression analysis on the GSE16011. Finally, 24 genes significantly related to grade and prognosis were obtained. In addition, there is no report about CACNG2, JPH3, TUBB6 (tubulin β 6 class V), NRSN1, FAM19A2, NALCN, CDH18, GNAL on glioma.
- Wannan Medical College China (People's Republic of)
- First Affiliated Hospital of Jiangxi Medical College China (People's Republic of)
- First Affiliated Hospital of Wannan Medical College China (People's Republic of)
Adult, Aged, 80 and over, Male, Bioinformatics, Brain Neoplasms, Gene Expression Profiling, Glioma, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Phenotype, Databases, Genetic, Biomarkers, Tumor, Humans, Female, Gene Regulatory Networks, Genetic Predisposition to Disease, Neoplasm Grading, Transcriptome, Aged
Adult, Aged, 80 and over, Male, Bioinformatics, Brain Neoplasms, Gene Expression Profiling, Glioma, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Phenotype, Databases, Genetic, Biomarkers, Tumor, Humans, Female, Gene Regulatory Networks, Genetic Predisposition to Disease, Neoplasm Grading, Transcriptome, Aged
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